Apo A-i and Apo E Interaction: beyond Lipoproteins

Apolipoproteins (Apo) A-I, A-II, A-IV, and E possess repeated amphipathic helical regions with the same genomic structure and are members of a multigene family that probably evolved from a common ancestral gene [1]. These apolipoproteins play pivotal roles in lipid transport and lipoprotein metabolism, and their carboxyl-terminal domain is critical for lipid binding [2]. The purpose of this commentary is to give a brief summary of the part of lipid metabolism in which apolipoproteins are involved as a major regulatory component.